The aim of this paper is identify the understanding of nurses, working in a teaching hospital in South of Brazil, caring on people who personify the opposite gender. Gender means individual’s behavior according their cultural interpretation about feminine and masculine while sex means biological male and female. Persons which embodied other gender role destabilize heteronormative’s social comprehensions. Medical technology, as a concept, involves from communication with the patient to the most modern techniques. Brazil’s Pubic Health Polices established, in 2008, the Transsexual Process. Ordinance 2803, in 2013, expands Transsexual Process in the Health Unic System. This is a qualitative research, supported in Cultural and Gender Studies and is part of a researche entitled Biotechnologies and care practices in an academic health service, CAAE: 46717815.8.0000.5343, approved by Ethics Committee of Santa Cruz do Sul University. Data results in two analytical units. First one shows nurses comprehention about the subject. The second, demonstrate their understanding about Transsexual Process and the knowledge obtained in their nursing schools. Discussion evidence interviewees are impregnated by moral conceptions that associate embodiment with socially inappropriate behavior and with perversion. Those kind of conceptions have strong impact on nursing care in a daily bases. It is concluded that continuing education should be offered to nurses so they can have the opportunity to think his views on transgender people as well as on the treatments available under Transexual Process in the Brazilian’s Health Unic System.